Mitochondrial function is key for maintaining cellular health, while mitochondrial failure is associated with various pathologies, including inherited metabolic disorders and age‐related diseases. In order to maintain mitochondrial quality, several pathways of mitochondrial quality control have evolved. These systems monitor mitochondrial integrity through antioxidants, DNA repair systems, and chaperones and proteases involved in the mitochondrial unfolded protein response. Additional regulation of mitochondrial function involves dynamic exchange of components through mitochondrial fusion and fission. Sustained stress induces a selective autophagy – termed (...) mitophagy – and ultimately leads to apoptosis. Together, these systems form a network that acts on the molecular, organellar, and cellular level. In this review, we highlight how these systems are regulated in an integrated context‐ and time‐dependent network of mitochondrial quality control that is implicated in healthy aging. (shrink)

SpanFor generations the elements of humor, poignancy, fantasy, and unfettered morality found within acclaimed children's author Roald Dahl's most famous tales have captivated both children and adults. Editor Jacob M. Held has collected the insights of today's leading philosophers into the significances, messages, and greater truths at which Dahl's rhythmic writing winks, revealing a whole new way to appreciate the creation of a man and mind to which readers of all ages are still drawn. /span...

Although there has been consistent interest in Marx and Marxism there has been little sustained interest in the origins of Marx’s ethical thought and his relation to the German philosophical tradition as a whole. Work has been done linking Marx to Fichte, and a great deal more linking him to Hegel. However, the fundamental concept joining them all is recognition, or interpersonal relations in general. In this regard, none of the German thinkers can be understood withoutfirst grasping their understanding of (...) the human person as one among many. This article begins this process for Marx. Although some literature has been devotedto the explication of Marx’s notion of species-being it is sparse and dated. In this article I proceed to reiterate how important species-being is as the foundationto Marx’s ethical philosophy. However, my main focus is on simply how to understand the concept itself. I, therefore, devote the majority of the article to ananalysis of Marx’s use of the concept in his early work as well as his critique of Ludwig Feuerbach’s use of it. This account provides the basis for understandingMarx’s concept of human essence and is the beginning of a project of rephrasing Marxian ethics around the concept of recognition thus reconnecting him to theGerman philosophical tradition. (shrink)

Anyone who loves Dr. Seuss or is interested in philosophy will find this book to be intriguing and enlightening.

In light of scientific advances such as genomics, predictive diagnostics, genetically engineered agriculture, nuclear transfer cloning, and the manipulation of stem cells, the idea that genes carry predetermined molecular programs or blueprints is pervasive. Yet new scientific discoveries—such as rna transcripts of single genes that can lead to the production of different compounds from the same pieces of dna—challenge the concept of the gene alone as the dominant factor in biological development. Increasingly aware of the tension between certain empirical results (...) and interpretations of those results based on the orthodox view of genetic determinism, a growing number of scientists urge a rethinking of what a gene is and how it works. In this collection, a group of internationally renowned scientists present some prominent alternative approaches to understanding the role of dna in the construction and function of biological organisms. Contributors discuss alternatives to the programmatic view of dna, including the developmental systems approach, methodical culturalism, the molecular process concept of the gene, the hermeneutic theory of description, and process structuralist biology. None of the approaches cast doubt on the notion that dna is tremendously important to biological life on earth; rather, contributors examine different ideas of how dna should be represented, evaluated, and explained. Just as ideas about genetic codes have reached far beyond the realm of science, the reconceptualizations of genetic theory in this volume have broad implications for ethics, philosophy, and the social sciences. Contributors. Thomas Bürglin, Brian C. Goodwin, James Griesemer, Paul Griffiths, Jesper Hoffmeyer, Evelyn Fox Keller, Gerd B. Müller, Eva M. Neumann-Held, Stuart A. Newman, Susan Oyama, Christoph Rehmann-Sutter, Sahotra Sarkar, Jackie Leach Scully, Gerry Webster, Ulrich Wolf. (shrink)

This chapter rehearses the historical discourse over pornography with the intent of orienting the reader to the discourse and motivating a more constructive approach to dealing with pornography. Topics covered include pornography and obscenity law in the context of First Amendment protections to freedom of speech, pornography as harmful, including the arguments that pornography causes sexual violence or foments discrimination, the value of pornography, and whether pornography in general, and pornographic films in particular are art. The overall approach to this (...) chapter is exploratory and the conclusions offered are tentative. The goal of this piece is simply to motivate a more robust understanding of pornography, its place in society, and its place in the artworld. (shrink)

This collection of essays examines the wisdom of Dr. Seuss and the philosophical insights that his classic children's books hold for adults. Whether exploring morality, compassion, or conflict resolution, Dr. Seuss's works are a guide to living well, and being the best person you can be.

This chapter contains sections titled: Defining “Obscenity” Will We Know It When We See It? Here We Go Again Anti‐Porn Feminists, or the Best Answer to Bad Speech is Less Speech Conclusion Notes.

Haunting us with such unforgettable stories as The Shining, Shawshank Redemption, Salem s Lot, Carrie, The Green Mile, and Pet Semetary, Stephen King has been an anchor of American horror, science fiction, psychological thrillers, and suspense for over forty years. His characters have brought chills to our spines and challenged our notions of reality while leaving us in awe of the perseverance of the human spirit. As the first book in the new Great Authors and Philosophy series, Stephen King and (...) Philosophy reveals some of the deeper issues raised by King s work. From retribution, freedom, and moral relativity, to death and insanity, the chapters of this book expose how King s stories access the questions and fears that nag each of us in the middle of night.". (shrink)

It's time to pick up your fedora and embark on a philosophical journey through Discworld! Terry Pratchett is world-famous for the narrative verve and surreal humour of his novels. But now meet another Terry Pratchett – a man of serious metaphysical ideas and sophisticated philosophical insights. In Philosophy and Terry Pratchett thirteen professional philosophers survey such key philosophical issues as personal identity, the nature of destiny, the value of individuality, the meaning of existentialism, the reality of universals and the existence (...) of alternative realities. In considering these and many other equally fascinating themes, close reference is made to more than 35 Discworld novels as well as to the ideas of some of history's greatest philosophers including Aristotle, Hobbes, Rousseau, Kant, Mill, Kierkegaard, Wittgenstein and Rawls. During your journey, you will be surprised by numerous provocative conclusions including the startling claim that the existence of Discworld is logically possible! (shrink)

Anti-Porn activists have argued for decades that pom is discrimination, it hamis women as a class. The Pro-porn response has been to dismiss these concems, laud the First Amendment, or argue that pornography is a valuable contribution to society. The debate has progressed little beyond this stage. In this article, I argue that it is time to frame the pomography debate as a discussion on sexualized media in general. Recent research indicates that the negative results often attributed to hard-core pornography, (...) such as sexist attitudes, lack of empathy for women, objectification, etc., are attributable to sexualized media as a whole. Pornography is, therefore, an infelicitous target. The solution to this problem is not the prohibition or litigation of one narrow aspect of this phenomenon, hard-core pornography, but the regulation of the producers of sexualized media in conjunction with efforts to educate consumers. (shrink)

James Bond 007 strode into the human imagination in the novel Casino Royale in 1953 and hit the movie screens with Dr. No in 1962. He has become one of the best-known personalities, real or imagined, in global history. One out of every four people in the entire world has now seen a Bond movie, and every month thousands of new readers become addicted to Ian Fleming’s original Bond stories. In James Bond and Philosophy, seventeen scholars examine hidden philosophical issues (...) in the hazardous, deceptive, glamorous world of Double-0 Seven. Is Bond a Nietzschean hero who graduates "beyond good and evil"? Does Bond paradoxically break the law in order, ultimately, to uphold it like any "stupid policeman"? What can Bond’s razor-sharp reasoning powers tell us about the scientific pursuit of truth? Does 007’s license to kill help us understand the ethics of counterterrorism? What motivates all those despicable Bond villains—could it be a Hegelian quest for recognition? (shrink)

Wonder Woman and her fellow Amazons serve the full Greek pantheon, worshipping Aphrodite and Athena in particular. But Wonder Woman's realm is also home to Roman gods, African and Egyptian gods, and the new gods including Darkseid, Highfather, Orion, and Metron. Wonder Woman speaks to loyalty, integrity, and honor. She speaks to the best in people, as they relate to each other and care for one another. These values can be enough to keep people going, this orientation is what they (...) seek, and this is what they can know, what they understand to be true. Perhaps if they are seeking a god in order to find their place, they might look to Wonder Woman and her Amazonian virtues. They could do worse than submit to the loving authority of Princess Diana, god of war. (shrink)

Gay marriage is an issue that almost everyone has an opinion about. As with most controversial topics, South Park has also had its say. This chapter centers around one particular episode of South Park, “Follow That Egg!” Recent events show that although the episode may be getting old, the issue and the themes raised in it are as topical as ever. There are many arguments for and against gay marriage. The author looks at the most familiar arguments on both sides (...) and demonstrates that they usually miss the point, are entirely irrelevant, or are just bad arguments. In so doing, the author hopes to map out the landscape of the gay marriage debate and show how barren it is. The only real case for gay marriage is rooted in America's political liberal tradition of “negative liberty.”. (shrink)

The title of this dissertation is a question: Is there a future to Marxist humanism? The work itself is an affirmative answer. The motive behind asking this question is the perennial debate surrounding the relevance of Marxism as a school of social and political thought. There are aspects of Marxism that are, arguably, no longer tenable, yet there are others that are more relevant today than ever. It is the argument of the following dissertation that Marxist humanism is of continued (...) relevance as both an analytical tool as well as a fertile ground for a political project of emancipation. However, the notion of a uniquely "Marxist humanism" is problematic. The fact that it is "Marxist" might lead to the confusion that it is thus based solely on the teachings of Karl Marx. Although his works provide the groundwork to the present project, it is the spirit and not necessarily the letter of Marxism that motivates the following discussion. That is, Marx's humanist project can continue without necessarily relying on his more questionable doctrines. The spirit of Marxist humanism lies in its demand for human well-being through mutual recognition achieved within an appropriately amenable social space wherein economic relations form the foundation to other equally as important intersubjective relationships. Marxist humanism is concerned primarily with the promotion of human values, namely, the alleviation of suffering and the promotion of human flourishing through a systemic change in the structure of society, beginning with economics but encompassing all areas of interpersonality... (shrink)

Particularly, but not exclusively, in Germany, concerns are uttered as to the consequences of modern biotechnological advances and their range of applications in the field of human genetics. Whereas the proponents of this research are mainly focussing on the possible knowledge that could be gained by understanding the causes of developmental processes and of disease on the molecular level, the critics fear the beginnings of a new eugenics movement. Without claiming a logical relationship between genetic sciences and eugenics movements, it (...) is nevertheless suggested in this article that a connection between both can become established when the distinction between scientifically validated statements on one hand and guiding hypotheses and assumptions on the other hand is blurred, as is observed particularly when scientists report their results to the public. This claim is demonstrated in comparisons between the current state of scientific knowledge on the role of genes in development and causation of diseases, and the way this is presented to the public. It is required that a debate on biotechnology should include reflections on the validity of claims made by scientists. (shrink)

Even as it skirts mainstream contemporary culture, pornography remains a social taboo; there still exist strong biases both in favor and against it. With chapters addressing imagination, gender, power relationships, truth claims, aesthetics, and both pro and anti-porn slants, this book presents a balanced view of pornography in modern society.

This is the 8th edition of the book, with eight new essays to the volume. Table of contents: Are We Having Sex Now or What? (Greta Christina); Sexual Perversion (Thomas Nagel); Plain Sex (Alan Goldman); Sex and Sexual Perversion (Robert Gray); Masturbation and the Continuum of Sexual Activities (Alan Soble); Love: What’s Sex Got to Do with It? (Natasha McKeever); Is “Loving More” Better? The Values of Polyamory (Elizabeth Brake); What Is Sexual Orientation? (Robin Dembroff); Sexual Orientation: What Is It? (...) (Kathleen Stock); Asexuality (Luke Brunning and Natasha McKeever); LGBTQ ... Z? (Kathy Rudy); How to Be a Pluralist About Gender Categories (Katharine Jenkins); The Negotiative Theory of Gender Identity and the Limits of First-Person Authority (Burkay Ozturk); Racial Sexual Desires (Raja Halwani); Sex and Technology: The Ethics of Virtual Connection (Neil McArthur); A Realist Sexual Ethics (Micah Newman); Sexual Morality and the Concept of Using Another Person (Thomas Mappes); Sexual Use (Alan Soble); Dark Desires (Seiriol Morgan); The Harms of Consensual Sex (Robin West); Casual Sex, Promiscuity, and Objectification (Raja Halwani); Is Prostitution Harmful? (Ole Martin Moen); BDSM (Shaun Miller); Two Views of Sexual Ethics: Promiscuity, Pedophilia, and Rape (David Benatar); Sexual Gifts and Sexual Duties (Alan Soble); A Bibliography of the Philosophy of Sex . (shrink)

With twenty-five essays, eight of which are new to this edition, this best-selling volume examines the nature, morality, and social meanings of contemporary sexual phenomena.

This best-selling volume examines the nature, morality, and social meanings of contemporary sexual phenomena. Updated and new discussion questions offer students starting points for debate in both the classroom and the bedroom.

As one of the most important ethicists to emerge since the Second World War, Alan Gewirth continues to influence philosophical debates concerning morality. In this ground-breaking book, Gewirth's neo-Kantianism, and the communitarian problems discussed, form a dialogue on the foundation of moral theory. Themes of agent-centered constraints, the formal structure of theories, and the relationship between freedom and duty are examined along with such new perspectives as feminism, the Stoics, and Sartre. Gewirth offers a picture of the philosopher's theory and (...) its applications, providing a richer, more complete critical assessement than any which has occurred to date. (shrink)

This best-selling volume examines the nature, morality, and social meanings of contemporary sexual phenomena. Updated and new discussion questions offer students starting points for debate in both the classroom and the bedroom.

This is a unique, groundbreaking collection of autobiographical essays by leading women in philosophy. It provides a glimpse at the experiences of the generation that witnessed, and helped create, the remarkable advances now evident for women in the field.